Get rid of household clutter
The Vietnam Veterans of America accept donations of clothing, shoes, books, small electronics, household items, and many more things. Best of all, they will pick up your donation at your home in Eastern MA. You can even schedule a pickup by e-mail.
I've called the Big Brother Big Sister Foundation a few times this past year as well. They pick up at your door. Furniture and a few other items are only picked up in the local, Boston area though.
Thanks for mentioning this...I don't live in the area but other very worthy charities are always willing to pick up our usable, donated items!